A new silver 1D-coordination polymer with bridging 2-aminopyrimidine, synthesis, characterization and antibacterial activity

Abstract

A new silver(І) complex formulated as [Ag(μ-amp)(ONO₂)]_n (1) (amp = 2-aminopyrimidine) was synthesized and characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction. Its thermal stability was studied by TGA/DTA. The bridging 2-aminopyrimidine ligands connect Ag(I) ions into a polymeric chain extended along the a axis; the chains are connected by nitrate anions and Ag…Ag interactions into 2 D arrays parallel with ac; these arrays are finally connected by hydrogen bonds into a three-dimensional network. In vitro antibacterial activities of 1 on Staphylococcus aureus (ATCC25923), Enterococcus faecalis (ATCC29219), Pseudomonas aeruginosa (ATCC27853) and Escherichia coli (ATCC25922) as important pathogens in producing infection in humans were investigated. Antibacterial activities were studied by determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The silver 1 D-coordination polymer with appropriate concentrations has good efficacy on these microorganisms. Escherichia coli is most sensitive to the complex (MIC: 0.009 µg/mL).

Graphical Abstract

Keywords:

• Silver coordination polymer
• aminopyrimidine
• In vitro
• antibacterial activity
• crystal structure
• hydrothermal synthesis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by Science and Research Branch, Islamic Azad University. The crystallographic part was supported by the project 15-12653S of the Czech Science Foundation using instruments of the ASTRA lab established within the Operation program Prague Competitiveness - project CZ.2.16/3.1.00/24510.