Cu(II) and Co(II) coordination polymers: protective activity on the ovarian injury caused by chemotherapy by enhancing the secretion of vascular endothelial growth factor

Abstract

Reactions of Cu(II) or Co(II) salts and 2-(4-carboxyphenoxy)terephthalic acid (H₃cpota) with N-heterocyclic donors (1,10-phenanthroline (phen) or 4,4′-bipyridine (4,4′-bpy)) formed two multidimensional CPs, [Cu(μ₃-Hcpota)(phen)]_n·nH₂O (1) and [Co₂(μ₄-cpota)(μ₂-4,4′-bpy)(μ₃-OH)]_n·nH₂O (2). The apoptosis percentage of ovarian cells after cyclophosphamide (CTX) exposure and treatment with 1 and 2 was evaluated by Annexin V-FITC detection kit. In addition, the secretion of vascular endothelial growth factor was measured with ELISA (enzyme linked immunosorbent assay detection kit).

Graphical Abstract

Keywords:

• Coordination complexes
• ovarian cells
• V-FITC
• ELISA

Disclosure statement

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

Data availability

The data used to support the findings of this study are included within the article.

Additional information

Funding

The research was supported by Science Research Foundation of Ningxia Medical University (XZ2017015), Ningxia Medical University Youth Backbone Talent Training Program (30120103), Innovation Platform of Obstetrics and Gynecology and Open Subject of Key Specialties in Ningxia Medical University (Z2020001), Ningxia Natural Science Foundation (NZ17174).

The research was supported by Science Research Foundation of Ningxia Medical University (XZ2017015), Ningxia Medical University Youth Backbone Talent Training Program (30120103), Innovation Platform of Obstetrics and Gynecology and Open Subject of Key Specialties in Ningxia Medical University (Z2020001), Ningxia Natural Science Foundation (NZ17174).