Synthesis, crystal structures and urease inhibition of copper, nickel and zinc complexes derived from 4-chloro-2-((pyridin-2-ylmethylene)amino)phenol

Abstract

A series of copper, nickel and zinc complexes, [CuClL] (1), [CuBrL] (2), [NiL₂] (3), [ZnL₂] (4) and [Zn₂I₂L₂] (5), where L is the deprotonated form of 4-chloro-2-((pyridin-2-ylmethylene)amino)phenol, have been synthesized and characterized by elemental analysis, IR and UV-Vis spectra. The structures of the complexes were further confirmed by single crystal X-ray diffraction. The Cu ions in 1 and 2 are in square planar coordination. The Ni and Zn ions in 3 and 4 are in octahedral coordination. The coordination of the Zn ions in centrosymmetric complex 5 is between square pyramidal and trigonal bipyramidal. The copper complexes have excellent urease inhibitory activity.

GRAPHICAL ABSTRACT

KEYWORDS:

• Schiff base
• copper complex
• nickel complex
• zinc complex
• crystal structure
• urease inhibition

Supplementary material

CCDC—2121950 (1), 2121951 (2), 2121952 (3), 2121953 (4) and 2121955 (5) contain the supplementary crystallographic data for this article. These data can be obtained free of charge at http://www.ccdc.cam.ac.uk/const/retrieving.html or from the Cambridge Crystallographic Data Centre (CCDC), 12 Union Road, Cambridge CB2 1EZ, UK; Fax: [phone] or E-mail: [email protected].

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was financially supported by the high level scientific research achievement funding program of Liaoning Normal University (grant number 21GDL003).