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Journal of Toxicology and Environmental Health Volume 50, 1997 - Issue 5
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Original Articles

UPPER RESPIRATORY TRACT SURFACE AREAS AND VOLUMES OF LABORATORY ANIMALS AND HUMANS: CONSIDERATIONS FOR DOSIMETRY MODELS

M. G. Ménache Duke University Medical Center, Durham, North Carolina, USAView further author information
,
L. M. Hanna Sciences International, Inc., Alexandria, Virginia, USA
,
E. A. Gross Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA
,
S.-R. Lou Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
,
S. J. Zinreich Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
,
D. A. Leopold Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
,
A. M. Jarabek U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
F. j. Miller Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA
 show all
Pages 475-506 | Received 15 Jun 1996, Accepted 05 Sep 1996, Published online: 25 Sep 2007
 
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Abstract

To facilitate the development of regional respiratory tract dosimetry comparisons between laboratory animal species and humans, published surface area (SA) and volume (VOL) data for the upper respiratory tract (URT) were reviewed. The review of the literature revealed that (1) different studies used different techniques to prepare specimens and make measurements, (2) different areas of the URT were measured, and (3) URT surface

Additional information

Notes on contributors

M. G. Ménache

Address correspondence to Dr. Margaret G. Menache, Duke University Medical Center, P.O. Box 3210 Pulmonary, Durham, NC 27710, USA. E-mail: [email protected].

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