SOLUBILITY OF LAMOTRIGINE IN BINARY AND TERNARY MIXTURES OF PEGS 200, 400, AND 600 WITH ETHANOL, PG, AND WATER AT 298.2 K

Abstract

Experimental solubilities of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (lamotrigine) in binary and ternary solvents of polyethylene glycols (PEGs) 200, 400, and 600 with ethanol and water, and PEGs 200, 400, and 600 with propylene glycol (PG) and water at T = 298.2 K are reported. The Jouyban-Acree model was used to fit solubility data of lamotrigine in the binary and ternary solvent mixtures (145 data points) in which the overall mean relative deviation (OMRD %) was 11.5%. The density of the solute-free solvent mixtures was measured and employed to calculate the constants of the Jouyban-Acree model and then the density of the saturated solutions is predicted.

Keywords:

• Density
• Jouyban-acree model
• Lamotrigine
• Modeling
• Solubility
• Solvent mixture

Acknowledgments

The authors thank Daana Pharmaceutical Company for supplying some materials used in this study.

Notes

Experimental data are taken from a previous paper (Shayanfar et al., 2009), and the solvent compositions are converted to mass fractions.

^a Not significant.

^a Not significant.