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Abstract
The protective effect of NAD, FAD, ATP and p-benzoquinone administered singly or in combination to rats, was studied. The first three compounds were well tolerated (up to 640 mg/Kg body weight). However, p-benzoquinone showed a high toxicity, so it was not considered for in vivo experiments. Animals were irradiated in a 137Cs gamma source (0.8 Gy/min) and the lethal dose (LD(50/30)) was 7.7 Gy.
The percentage of survivors, mean survival time, average day of death and Kaluszyner's survival coefficient1 was scored.
The effect obtained with the mixture NAD-FAD 20 mg/Kg (1:1) Kz = 0.49) was higher than the effect obtained with the single compound at the same total concentrations. (NAD Kz = 0.26; FAD Kz = 0.34).
The mixture NAD-FAD 280 mg/Kg (1:1) showed a protective effect (Kz = 0.60) similar to NAD 280 mg/Kg (Kz = 0.59), but better than FAD, (Kz = 0.49) at the same concentration.
For concentrations of 280 mg/Kg (1:1), the combinations NAD-ATP and FAD-ATP showed a protective effect higher than each compound administered singly. Similar results were found with NAD-FAD-ATP mixture 280 mg/Kg (1:1:1); NAD, ATP and the mixture NAD-ATP and FAD-ATP at a total concentration of 560 mg/Kg.