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Journal of Obstetrics and Gynaecology Volume 36, 2016 - Issue 8
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Original Article

Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

Gulistan Sanem SaribasFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey; Correspondence[email protected]
,
Deniz ErdoganFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey;
,
Guleser GoktasFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey;
,
Seda Nur AkyolFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey;
,
Ibrahim Murat HirfanogluFaculty of Medicine, Department of Pediatrics, Neonatology Unit, Gazi University, Ankara, Turkey;
,
Seren Gulsen GurgenSchool of Vocational Health Services, Department of Histology and Embryology, Celal Bayar University, Manisa, Turkey
,
Neslihan CoskunFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey;
&
Candan OzogulFaculty of Medicine, Department of Histology and Embryology, Gazi University, Ankara, Turkey;
show all
Pages 1086-1092 | Received 05 Sep 2015, Accepted 23 Jun 2016, Published online: 27 Oct 2016
 
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Abstract

The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.

Acknowledgements

This work has supported by Gazi University Scientific Research Project Unit, Ankara, Turkey [grant number: 01/2010-20].

Disclosure statement

The authors report no declarations of interest.

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