Expression and significance of aquaporin-2 and serum hormones in placenta of patients with preeclampsia

Abstract

To evaluate the relationship between serum hormone or aquaporin-2 (AQP-2) and preeclampsia, patients with severe preeclampsia (A group), mild preeclampsia (B group), chronic hypertension (C group) and normal pregnant women (D group) were recruited and analysed. The AQP-2 level in placenta tissues was detected and the correlations of AQP-2 with serum hormone levels were analysed using linear correlation regression analysis. The differences of alpha foetal protein (AFP) and human chorionic gonadotropin (HCG) levels during mid-pregnancy, as well as the levels of AFP, HCG, unconjugated oestriol and progesterone during late pregnancy were significant among A, B, C and D groups (p < .05). The AQP-2 level in placenta tissues was higher in A group than that in other groups (p < .05). The AQP-2 was correlated with HCG (p < .05). In conclusion, AQP-2 may be involved in the development of severe preeclampsia, which may be related to serum HCG.

Keywords:

• Aquaporin-2
• severe preeclampsia
• chronic hypertension
• serum hormone
• pregnancy

Acknowledgements

The study was supported by the Beijing XiCheng District Health Bureau of Young Scientists (Science Nova) training projects (2012) [project No. XWKX2012-06].

Disclosure statement

The authors declare that they have no competing interests.

Ethics approval and consent to participate

This study was approved by Ethics Committee of Beijing Friendship Hospital, Capital Medical University.

Additional information

Funding

The study was supported by the Beijing XiCheng District Health Bureau of Young Scientists (Science Nova) training projects (2012).