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Research Article

Developmental neurotoxicity after penconazole exposure at embryo pre- and post-implantation in mice

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Pages 135-146 | Published online: 19 May 2020
 

ABSTRACT

The present study was conducted to evaluate the effect of penconazole fungicide at a low dose (2.5 mg/kg b.w.) during embryogenesis in either the pre- or post-implantation of embryos. Females were determined pregnant according to the presence of vaginal plug and then grouped into control and penconazole-exposures at high doses (30, 20, 10, and 5 mg/kg b.w.). These high doses provoked foetoresorptionin the first experiment. Thus, a low dose (2.5 mg/kg b. w.) was used in either the pre- or post-implantation of embryos to clarify the embryotoxicity without mortality on the developing brain and eye. Results indicate a developmental delay of the cerebral hemisphere, hippocampus, cerebellum (lobulation) and induced retinopathy during eye development in post-implantation of penconazole treated group. Also, the effect of penconazole at low dose provoked a decrease in the expression of α-synuclein in the hippocampus, cerebellum, and ganglion cell layer of the developing brain and eye. In conclusion, exposure to PEN fungicide during pregnancy at a dose (2.5 mg/kg) induces alterations in the developing brain and eye tissues.

Disclosure statement

The authors declare that there is no conflict of interest.

Additional information

Funding

The work was supported by the Zoology department, Faculty of Science, Sohag University, Egypt.

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