Comparison of several commonly used detection indicators of cell senescence

Abstract

Cell senescence is the state of irreversible growth arrest that can be triggered by a variety of different cellular stresses. Currently, the commonly used detection indicators involved in the study of cell senescence include senescence-associated β-galactosidase, Clusterin, Telomeres/Telomerase, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, senescence marker protein-30, tumor suppressor genes p53 and p16, and other indicators such as Ki67 and decoy receptor 2. These indicators are widely used in the study of cell senescence, each with its own characteristics, advantages, and disadvantages. This review summarizes several commonly used cell senescence indicators and compares their accuracy, credibility, specificity, and the scope of their potential application.

Keywords:

• Detection indicators
• cell senescence
• SA-β-gal
• clusterin
• p16

Acknowledgments

The authors thank all of the individuals in this laboratory for their valuable ideas and suggestions.

Disclosure statement

The authors have no conflicts of interest to declare in relation to this article.

Additional information

Funding

This research was financially supported by National Natural Science Foundation of China (NO. 81773478).