HPLC Study Off Some Biologically Active Quinazolines

Abstract

Experimental log

(R_M) values were determined for a series of pharmacologically active quinazolines. Statistically significant linear relationships were found between log k' and log P, log k and Hansch's parameter. The retention indices (Rl) of these compounds were measured, and a statistically significant linear relationship was also found between log P and RI. The resolution factors and selectivity were determined for some pairs of the tested compounds. The relationship between the structure and δ log k was interpreted. The best linear relationship was found at 60% methanol and water for G₁₈ and C₈ columns.