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Abstract
The area of research involving the on-line combination of mass spectrometry and liquid chromatography has recently experienced a period of intense growth. A dependable LC-MS combination is eagerly awaited for by many researchers. The salient features of the combination aspect of LC-MS are analyzed in this review. LC-MS may operate in either the off-line or the on-line mode. The off-line mode is illustrated with the analytical measurement of biologically important peptides.