Chromatographic Characterization of Neurotensin Fragments, Neurotensin, and Other Intestinal Peptide Inhibitors of Gastric Acid Secretion

Abstract

Neurotensin and other small intestinal peptides that may inhibit gastric acid secretion have not previously been separated chromatographically from each other. We report two HPLC gradient systems that effectively resolve 11 different peptides of small intestinal origin, and that may be useful in the characterization of new peptides isolated from the small intestine or from portal plasma.