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Archives of Andrology
Journal of Reproductive Systems
Volume 50, 2004 - Issue 2
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Research Article

EFFECT OF TREATING ANTIBODY-COATED SPERM WITH CHYMOTRYPSIN ON PREGNANCY RATES FOLLOWING IUI AS COMPARED TO OUTCOME OF IVF/ICSI

J. H. CHECK University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology/Infertility, Camden, New Jersey, USA
,
W. HOURANI University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology/Infertility, Camden, New Jersey, USA
,
M. L. CHECK University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology/Infertility, Camden, New Jersey, USA
,
V. GRAZIANO University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology/Infertility, Camden, New Jersey, USA
&
E. LEVIN University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology/Infertility, Camden, New Jersey, USA
Pages 93-95 | Published online: 09 Jul 2009
 
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Abstract

Males with 100% of their sperm coated by antisperm antibody have a very small chance of achieving a pregnancy by intercourse or conventional intrauterine insemination (IUI). A previous study found that treatment of the sperm with the protein digestive enzyme chymotrypsin improved the efficacy of IUI. The present study was designed to corroborate or refute this previous study and compare efficacy to IVF with ICSI. This time the subjects were an even more difficult group with 100% of the sperm coated by autoantibodies.

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