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Archives of Andrology
Journal of Reproductive Systems
Volume 51, 2005 - Issue 4
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Virology

HUMAN PAPILLOMAVIRUS HPV-16 DNA AS AN EPITHELIOTROPIC VIRUS THAT INDUCES HYPERPROLIFERATION IN SQUAMOUS PENILE TISSUE

Edith L. Salazar Medical Research Coordination, Medical Research Unit of Endocrine Disease, Social Security Mexican Institute, Mexico City, Mexico
,
E. Mercado Reproduction Biology Department, Metropolitan Autonomous University, Iztapalapa, Mexico
&
L. Calzada Health Center (T-III) Dr. Manuel Escondria, Sanitary Jurisdiction Alvaro Obregon of the Public Health Services of Distrito Federal, Mexico City, Mexico
Pages 327-334 | Published online: 09 Jul 2009
 
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Abstract

The prevalence of human papillomavirus HPV-16DNA sequences in 57 penile carcinoma biopsies was examined using the polymerase chain reaction (PCR) with type specific internal probes, employing HPV consensus primers from the L1 region. The cases comprised 39 typical squamous cell carcinoma and 18 specimens with different subtype. PCR products were analyzed and HPV-16DNA was detected in a high percentage of specimens. Thirty-eight biopsies were HPV-16DNA positive. This determination was correlated with cellular differentiation and growth pattern. Our data corroborates that squamous cell carcinoma was invariably associated with HPV-16DNA.

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