Abstract
A polymer membrane imprinted with quercetin has been synthesized in the presence of nickel(II) acetate as a metal ion mediator. A mixture of methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), tetrahydrofuran (THF) – methanol (3:1 v/v) as a solvent and Darocur® 1173 (2-hydroxy-2-methyl-1-phenyl-propan-1-one) as a photoinitiator was polymerized on a track-etched membrane (pores 0.4 µm) used as a support. The polymer formed regular layers on both sides of the membrane and filled the pores. The highest initial flux of the template of 1.8 · 10−7 mol · cm−2 · h−1 was observed for its diffusion from THF/acetate buffer (20:80, v/v) into THF. Membranes polymerized with nickel(II) were both more permeable and more selective. The maximum selectivity factors, calculated by using percent permeation, were 4.5 (quercetin/rutin) and 4.9 (quercetin/naringenin).
ACKNOWLEDGEMENTS
The authors are grateful to the Russian Foundation for Basic Research for financial support (project No 10-03-01023-a) and Elena Khanonina (BASF Russia) for the sample of Darocur® 1173.
Notes
*Notes. References to the publications of 1990-s can be found in paper (Citation3); the fluxes do not exceed 2 · 10−8 mol · cm−2 · h−1. Many other MIMs have only been characterized in sorption or filtration experiments (Citation15,Citation32,Citation34,Citation35,Citation43), in which cases the diffusion flux data are unavailable.
*Note. For conditions, see Fig. .
*According to the position of the membrane during polymerization.
Notes. Permeation across initial track-etched TM under these conditions was 29 ± 3%. Data have been obtained form 5 diffusion runs, and uncertainties calculated for the significance level of 0.95.
*Note. For conditions, see Fig. .
*Notes. Feed: THF:0.5 M acetate buffer, pH 5.4 (20:80, v/v); initial concentrations: 5 · 10−4 M quercetin, 1.5 · 10−3 M Ni(CH3COO)2; receiving phase: THF; t = 15 min; n = 3, P = 0.95. For polymerization conditions, see Fig. .
*Mixed directly before diffusion.
**Quercetin and Ni(CH3COO)2 solutions were mixed 15 min before diffusion.
*Notes. For other polymerization and diffusion conditions, see Fig. . Average values and uncertainties were calculated from 3 parallel diffusion runs (P = 0.95).
*Note. For other conditions, see Fig. .
*Note. For other conditions, see Fig. .