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Separation Science and Technology Volume 52, 2017 - Issue 6
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Chromatography

Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography

Boyan LiuDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. China;University of Chinese Academy of Sciences, Beijing, P.R. ChinaView further author information
,
Beitao DongDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. China;University of Chinese Academy of Sciences, Beijing, P.R. ChinaView further author information
,
Xiaofan YuanDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. ChinaCorrespondence[email protected]
View further author information
,
Yuanheng GuoDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. China;University of Chinese Academy of Sciences, Beijing, P.R. ChinaView further author information
,
Lijun ZhangDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. China;University of Chinese Academy of Sciences, Beijing, P.R. ChinaView further author information
&
Bing ZhaoDivision of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R. ChinaCorrespondence[email protected]
View further author information
Pages 1114-1121 | Received 18 Jul 2016, Accepted 09 Jan 2017, Published online: 22 Feb 2017
 
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ABSTRACT

An efficient method for simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum was developed. The entire procedure consisted of two separation steps. The first step was enrichment of chlorogenic acid from the crude extract by NKA-II macroporous resin. The purity of chlorogenic acid increased from 5.3% to 20.9% with a recovery of 88.7%. Subsequently, polyamide resin was used to achieve a higher purity. After the polyamide resin treatment, the main toxin 9-oxo-10,11-dehydroageraphorone was removed and the purity of chlorogenic acid reached 86.5% with a recovery of 84.8%. It provided a new way for the utilization of E. adenophorum.

Acknowledgement

The authors thank Professor Yuchun Wang for his help with the manuscript.

Funding

The authors gratefully acknowledge the financial supports by Panzhihua Xiyu Biotech Co., Ltd. (Sichuan, China).

Additional information

Funding

The authors gratefully acknowledge the financial supports by Panzhihua Xiyu Biotech Co., Ltd. (Sichuan, China).

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