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Separation Science and Technology Volume 53, 2018 - Issue 11
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Original Articles

Polyprenylated benzophenone-enriched extracts obtained using SC–CO2 from the dry ethanolic extract of Brazilian red propolis

Ana Luisa FiancoLaboratório de Operações Unitárias, Faculdade de Engenharia, PUCRS, Porto Alegre, Brazil
,
Aline Machado LucasLaboratório de Operações Unitárias, Faculdade de Engenharia, PUCRS, Porto Alegre, Brazil
,
Daniel FasoloLaboratório de Farmacognosia, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
,
Rafael Nolibos AlmeidaLaboratório de Operações Unitárias, Faculdade de Engenharia, PUCRS, Porto Alegre, BrazilORCID Iconhttp://orcid.org/0000-0002-5792-5392
ORCID Icon,
Bruna PippiLaboratório de Micologia Aplicada, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
,
Camila Martins GüezLaboratório de Micologia Aplicada, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
,
Alexandre FuentefriaLaboratório de Micologia Aplicada, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
,
Rubem M. Figueiró VargasLaboratório de Operações Unitárias, Faculdade de Engenharia, PUCRS, Porto Alegre, BrazilORCID Iconhttp://orcid.org/0000-0003-2696-8581
ORCID Icon,
Helder Ferreira TeixeiraLaboratório de Farmacognosia, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
,
Gilsane Von PoserLaboratório de Farmacognosia, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, BrazilORCID Iconhttp://orcid.org/0000-0003-2527-7500
ORCID Icon &
Eduardo CasselLaboratório de Operações Unitárias, Faculdade de Engenharia, PUCRS, Porto Alegre, BrazilCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8843-0694
ORCID Icon show all
Pages 1724-1731 | Received 19 Aug 2016, Accepted 02 Jan 2018, Published online: 16 Jan 2018
 
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ABSTRACT

Red propolis is a well-known potent antimicrobial source because of its various bioactive compounds. This work aims to submit a sample of Brazilian red propolis to supercritical CO2 extraction, with subsequent chemical characterisation by HPLC and UHPLC–MS, and to evaluate the antifungal activity against three strains of Candida glabrata. The method proved to be selective for the extraction of benzophenones. The results demonstrated a correlation between the presence of benzophenones and antifungal activity. The supercritical extract that seems to be the richest in benzophenones was the one obtained with a pressure of 300 bar and was the most active against the C. glabrata strains.

Abbreviations: SFE, Supercritical Fluid Extraction; MIC, Minimal Inhibitory Concentration; SC, Supercritical; BZP, benzophenones

Acknowledgments

The authors are grateful to the Brazilian agencies CAPES, CNPq and FAPERGS for the financial support. Special thanks are given to Dr. M. Holzschuh (Analytic Central, Faculdade de Farmácia-UFRGS) for recording the UPLC-DAD-QTOF-MS analyses.

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