A New solubility model for competing effects of three solvents: Water, ethanol, and supercritical carbon dioxide

ABSTRACT

This study aims to develop a new semi-empirical model to fit solute solubility in a mixture of solvents, viz. supercritical carbon dioxide, ethanol, and water, as well as to evaluate the effects of competing solvents on solubility. Therefore, the model was assessed by fitting the published solubility data and comparing it with the established semi-empirical models. The findings revealed that the new model gave the highest coefficient of determination, R² of 0.96 and had the lowest AARD (i.e., 3.88%), compared to other models. To conclude, the new model is feasible in determining three solvents’ solvation effects in one system.

KEYWORDS:

• New model
• supercritical carbon dioxide
• ethanol
• water
• solubility

Acknowledgements

The authors thank the Centre of Lipid Engineering and Applied Research (CLEAR) for the equipment used. The financial support from Universiti Teknologi Malaysia Iconic Grant (Q.J130000.4351.09G56) is gratefully acknowledged.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the UTM Post Doctoral Scheme [R.J130000.7113.05E53].