Distant C-H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity

Abstract

Activation/functionalization of inert C-H bond has undergone rapid growth in last decade and provides novel retro-synthetic disconnections for the synthesis of valuable molecules. The selectivity is often achieved by the use of directing group and is mainly limited to the proximal C-H bond. Initially, meta C-H activations were based on electronic or steric control and now it can be achieved by employing nitrile-based end-on-template as the directing group. The compilation of the remote C-H activation strategy will provide the useful linkage to the scientific community. This article is focused on recent progress in remote C-H activation, mechanistic understanding, and its applications in the field of total synthesis of targeted molecules.

Keywords:

• C-H activation
• Transition metals
• Directing groups
• Mechanism
• Selectivity
• Natural products

Additional information

Funding

The authors kindly acknowledge Director, CSIR-IHBT, and CSIR, New Delhi, India for providing necessary facilities and financial support (Project MLP0066). CSIR-IHBT comm. no. for this publication is 3784.