Effects of different montages of transcranial direct current stimulation on the risk of falls and lower limb function after stroke

Abstract

Background: Stroke is associated with high rates of falling and severe impairment of lower limb in patients who survive.

Objective: The aim of this study was to analyze the effectiveness of different montages of transcranial direct current stimulation (tDCS) on reducing falls and on lower limb function after acute stroke.

Methods: Sixty participants with acute stroke were randomly allocated into four groups with different electrode’s setups: anodal, cathodal, bilateral and sham tDCS. Each patient received 10 stimulation sessions (five consecutive days for two weeks). Four Square Step Test, Occurrence of Falling Index, Overall Stability Index, Falls Efficacy Scale – International, Berg Balance Scale, Six-minute walk test and Sit to Stand Test were measured at baseline, post-treatment, and at one- and three-month follow-up.

Results: At baseline, no differences between the groups in terms of clinical and demographic characteristics were found. However, after treatment and during follow up, all the groups that received active stimulation showed greater reduction in the risk of falls and improved performance of the lower limb’s motor skills when compared to the sham group. No significant differences were found between the three types of active montages in relation to the risk of falling. In relation to lower limb function, bilateral stimulation provided a higher improvement when compared to anodal and cathodal tDCS.

Conclusions: This is the first trial with different setups of tDCS on acute stroke patients. tDCS presents as an effective treatment strategy in reducing the risk of falls and improving lower limb function after a stroke.

ClinicalTrials.gov (NCT 02422173).

Keywords:

• Transcranial direct current stimulation
• risk of falls
• lower limb function
• stroke