ABSTRACT
Objectives: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.
Methods: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. 340 (32.7%) had diabetes and 246 (23.6%) had HUA. Diabetic patients were stratified by gender or age. Multivariate logistic regression was used to analyse the association between HUA and prognosis of AIS.
Results: HUA independently predicted poor discharge outcome of AIS in diabetic patients [OR (95% CI): 2.061 (1.042–4.077), p < 0.05]. Among diabetics, HUA selectively predicted a poor functional outcome of AIS at discharge in patients aged ≤75 years [OR (95% CI): 2.381 (1.115–5.085), p < 0.05]. Furthermore, in patients aged ≤75 years, HUA independently predicted poor discharge outcome of AIS in male diabetics [OR (95% CI): 2.684 (1.001–7.200), p < 0.05]. No association between HUA and prognosis of AIS was observed at 3-month, 6-month and 12-month follow-up, either in diabetics or nondiabetics.
Conclusions: HUA independently predicted poor in-hospital outcome of AIS in diabetic patients, especially in patients aged ≤ 75 years.
Acknowledgments
We thank all participants and medical staff for their strong support.
Disclosure statement
No potential conflict of interest was reported by the authors.
Ethical standards
This prospective cohort study was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.
Role of the Sponsor
The funding agency did not intervene at any stage of the study.
Author Contributions
Study design: Ying Tang, Jingbo Zhao.
Data collection: Ping Wang, Xinyan Li, Yu Zhang, Hong Wang, Hongwei Sun, Chaonming He.
Data analysis and interpretation of the results: Ping Wang, Jingbo Zhao.
Manuscript drafting: Ping Wang, Yun Zhai.
Manuscript edition: Ping Wang.
Administrative and material support: Ying Tang, Jingbo Zhao.
Study supervision: Ying Tang, Jingbo Zhao.
A Statement
This content has not been published or submitted for any publication.
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Notes on contributors
Ping Wang
Ping Wang, a second grade postgraduate in the Harbin Medical University, School of Public Health.
Xinyan Li
Xinyan Li, a second grade postgraduate in the Harbin Medical University, School of Public Health.
Chaoming He
Chaoming He, the chief physician in the department of neurology in the Third People’s Hospital of Hainan Province.
Yun Zhai
Yun Zhai, a physician in the department of neurology in the first Affiliated Hospital of Harbin Medical University.
Hongwei Sun
Hongwei Sun, a physician in the department of neurology in the first Affiliated Hospital of Harbin Medical University.
Yu Zhang
Yu Zhang, a third grade postgraduate in the Harbin Medical University, School of Public Health.
Hong Wang
Hong Wang, a third grade postgraduate in the Harbin Medical University, School of Public Health.
Yuna Wang
Yuna Wang, a second grade postgraduate in the Harbin Medical University, School of Public Health.
Jingbo Zhao
Jingbo Zhao, a professor of department of epidemiology in the Harbin Medical University.
Ying Tang
Ying Tang, the chief physician in the department of neurology in the first Affiliated Hospital of Harbin Medical University.