ABSTRACT
Objectives: FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).
Methods: Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between FOSL1 expression and overall survival (OS) in TCGA-LGG and subgroups.
Results: FOSL1 expression in LGG was ranked first among 21 different cancers. LGG with lower FOSL1 expression had longer OS (P < 0.001). The astrocytoma group had the highest FOSL1 expression and shortest OS, followed by oligoastrocytoma and oligodendroglioma (P < 0.05). The 1p19q co-deletion or IDH mutation subgroups had lower FOSL1 expression and longer OS (P < 0.001). Compared with the corresponding groups, LGG with lower FOSL1 expression had longer OS than the following groups: astrocytoma, oligodendroglioma, with/without 1p19q co-deletion, with IDH mutation, with radiation, and with pharmaceutical therapy (P < 0.05).
Discussion: FOSL1 is a prognostic marker in LGG and subgroups.
Acknowledgments
We thank H. Nikki March, PhD, from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.
Disclosure Statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
Notes on contributors
Jin Zhu
Jin Zhu is a postdoctoral researcher in the Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University.
Ya-Peng Zhao
Ya-Peng Zhao is an attending doctor in the Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University.
Yu-Qi Zhang
Yu-Qi Zhang is a professor of the Department of Neurosurgery, Yuquan Hospital, Tsinghua University.