The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy)

ABSTRACT

Aim

Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally.

Material and Methods

Twenty-eight male WAG/Rij rats were used. The effects of acute treatment with DEX (5, 25, and 50 mg/kg, i.p) on absence-like seizures, and related psychiatric comorbidity were assessed. The ECoG recording was taken for 180 min before and after drug injection. After drug injection and EcoG recording, anxiety-depression-like behavior was tested with the open field test for 5 min.

Results

The 5 mg/kg DEX significantly reduced the number and duration of SWDs percentage (p < 0.05) between 120 and 180 min, but 25 and 50 mg/kg DEX significantly increased the number and duration of SWDs percentage between 0 and 30 min (p < 0.05), and after 30 min the increase stopped (p > 0.05). And also, the 5 mg/kg DEX decreased the number and duration of SWDs percentage (p < 0.05) for 180 min (p < 0.05), but 25 and 50 mg/kg DEX administration did not alter (p > 0.05). The 5, 25, and 50 mg/kg doses of DEX significantly increased the duration of grooming (p < 0.05) but did not change the number of squares crossed (p > 0.05).

Conclusion

Low dose DEX reduced absence-like seizures, but care should be taken when using high doses in absence epilepsy. Also, it may be beneficial for painful diseases accompanied by anxiety-depression.

KEYWORDS:

• Epileptogenesis
• inflammation
• absence epilepsy
• dexketoprofen
• WAG/Rij rats

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Aras Erdil

Aras Erdil is an oral and maxillofacial surgeon in Sivas Dental Health Hospital. He is interested in the link between epilepsy and inflammation.

Mustafa Sami Demirsoy

Mustafa Sami Demirsoy is an oral and maxillofacial surgeon and lecturer at Sakarya University. He is interested in the link between epilepsy and inflammation.

Sefa Çolak

Sefa Çolak is an oral and maxillofacial surgeon in private practice. He is still working on drug interactions with epilepsy.

Esra Duman

Esra Duman got a Ph.D. degree on veterinary genetics at Ankara University. She is still working on the link between inflammation and epilepsy.

Orhan Sümbül

Orhan Sümbül is a neurologist and lecturer in Tokat Gaziosmanpasa Universty Hospital, Tokat, Turkey. He majors in epilepsy and headache and has several related publications.

Hatice Aygun

Hatice Aygün is a physiologist and researcher at the Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey. She majors in epileptogenesis and has several related publications.