Risk factors of cerebral aneurysms rupture in an Indonesian population

ABSTRACT

Background

The demographic, clinical, and angiographic features of ruptured aneurysms compared to unruptured cerebral aneurysms in Indonesia are still limited. This study aims to determine risk factors for rupture according to clinical patterns and morphological features in the Indonesian population.

Method

We retrospectively reviewed all cerebral aneurysm registries at the largest comprehensive stroke center in Indonesia from January 2019 to January 2022. We compared demographic and vascular risk factors as well as angiographic features between patients with ruptured and unruptured aneurysms with univariate and multivariate analyses.

Results

Of 275 patients, 231 (84%) had ruptured cerebral aneurysms. We found a significant difference between the ruptured and unruptured groups in variables such as age, hypertension, dyslipidemia, smoking, location, and type of aneurysm. It was found that only the anterior circulation site (OR 4.91, 95% CI 1.47–16.48; p < 0.01) and saccular type (OR 5.45, 95% CI 1.42–20.93; p = 0.01) were significantly linked to ruptured aneurysms.

Conclusion

Our findings revealed that anterior location and saccular type were substantially linked with ruptured aneurysms in the Indonesian population.

KEYWORDS:

• Cerebral aneurysm
• rupture
• risk factors
• Indonesian population
• predictors

Acknowledgments

The authors are delighted to acknowledge the board of directors at Mahar Mardjono National Brain Center Hospital. The authors also thank Dr. Melita and staff (Department of Radiology) for their outstanding expertise in cerebral aneurysm imaging.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

RK, BR, and BTP, and contributed to the conception, design, and acquisition of the study. BR, PW, and KG conducted the data analysis and wrote the manuscript. RK, BR, BTP, MK, AA contributed to manuscript revision. All authors contributed to read and approved the submitted version of the manuscript.

Ethics approval

Our study protocol was reviewed and approved by the Committee of Research Ethics (approval number LB.02.01/KEP/20/2022). The data we obtained for this study did not require written informed consent from the respective patients.

Data availability statement

All data generated or analyzed during this study are available. Further inquiries may be directed to the corresponding author.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.