Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

Abstract

Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.

Notes

^a Abbreviations are as follows: Hep3B, hepatitis 3B; HCC, hepatocellular carcinoma; LEC, Long-Evans Cinnamon.