Meat, Milk and Risk of Lymphoid Malignancies: A Case-Control Study in Uruguay

Abstract

In the time period 1996–2004, 697 cases with lymphoid neoplasms and 3606 controls with nonneoplastic conditions were included in a case-control study conducted in the Cancer Institute of Uruguay. They were administered a routine questionnaire that included 8 sections and a food frequency questionnaire focused on intakes of total meat, red meat, salted meat, barbecued meat, processed meat, milk, total vegetables and total fruits, and alcoholic beverages. Lymphoid cancers were analyzed by multiple polytomous regression. Red meat, salted meat, and milk were positively associated with risk of lymphoid cancers [odds ratios (OR) for the highest tertile vs. the lowest one of red meat = 1.68, 95% confidence interval (CI) 1.37–2.08, OR for whole milk = 2.92, 95% CI 2.63–3.63). On the other hand, plant foods, particularly total fruits, and alcoholic beverages (mainly red wine) were protective. We could conclude that these foods could play a significant role in the etiology of lymphoid malignancies.

ACKNOWLEDGMENTS

The authors acknowledge Drs. Luis Fierro, María T. Larrinaga, and Julio C Balbi for their valuable help in the design of the epidemiologic database of the Cancer Institute of Uruguay.