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Abstract
Objective: To study the effects of preoperative enteral nutrition (EN) on postoperative recent nutritional status (PRNS) in patients with Siewert II and III adenocarcinomas of esophagogastric junction (AEG) after neoadjuvant chemoradiotherapy (NCRT).
Methods: A total of 66 patients with resectable AEG (Siewert II and III) were randomly divided into two groups. The trial group accepted oral nutrition supplementation (ONS) for 7 days before surgery while the control not.
Results: Nutrition indexes were higher in trial group after surgery whereas the opposite was true for the diamine oxidase (DAO) and d-lactate (P < 0.05). The rate of malnutrition and nutritional risk became lower in trial group on the 8th day after surgery (P < 0.05). Injury levels of intestinal mucosa were more severe among control group. The recent prognosis was better in trial group. For patients with or without nutritional risks at admission, the PRNS and recent prognosis were improved by preoperative EN. Logistic regression analysis suggested that preoperative EN could be an independent protective factor of PRNS.
Conclusions: Preoperative EN may improve the PRNS and recent prognosis of patients with Siewert II and III AEG after NCRT.
Acknowledgments
We thank Li Wang (Laboratory Center of Electron Microscopy, Hebei Medical University), Yanning Chen (Department of Pathology, Institute of the Forth Hospital of Hebei Medical University), and Meixiang Sang (Research Center, the Fourth Hospital of Hebei Medical University) for the assistance with the experiments.
Informed Consent
Informed consent was obtained from all individual participants included in the study.
Disclosure Statement
The authors declare that they have no conflict of interest.