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Nutrition and Cancer Volume 70, 2018 - Issue 8
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Original Articles

The Protective Effects of Omega3 on Ubiquitination and Protamination of Rat Sperm after Bleomycin, Etoposide, and Cisplatin Treatment

Fatemeh HashemiDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;
,
Shahnaz RazaviDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-1726-9324
ORCID Icon &
Farnaz KhadiviDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; ;Department of Anatomical Sciences, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Pages 1308-1314 | Received 17 Jan 2018, Accepted 04 Sep 2018, Published online: 26 Nov 2018
 
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Abstract

The purpose of this study is evaluation the protective effect of omega3 on rat sperm protamination and ubiquitination after treatment with Bleomycin, Etoposide and Cisplatin (BEP) drugs. In present study, 40 male rats were divided into four groups: Control, BEP, Omega3 and BEP + Omega3. Sperm protamination and ubiquitination were assessed using chromomycin A3 and immunofluorescence staining respectively. The mean percentage of ubiquitinated sperm in BEP group was significantly increased relative to control group (P < .001). But, the mean percentage of sperm protamination significantly decreased in BEP group relative to control group (P < .001). Rats in BEP + Omega3 group showed a significantly decreased in the mean percentage of sperm ubiquitination as compared to BEP group (P < .05) while, sperm protamination increased significantly relative to BEP group (P < .001). Administration of Omega3 after chemotherapy showed an improvement in sperm ubiquitination and protamination. Our data indicated that omega3 after chemotherapy may be beneficial for chromatin remodeling during spermatogenesis following BEP treatment.

Acknowledgment

This research was supported by Isfahan University of Medical Sciences.

Disclosure Statement

The authors have no conflict of interest to declare.

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