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Abstract
Objectives: There are conflicting results for the association between vitamin B6 intake with reduced pancreatic carcinoma risk. Thus, a meta-analysis was performed to summarize the evidences from epidemiological studies.
Methods: We searched documents from PubMed-Medline, Web of Science, and Cochrane Library. The results were analyzed by using Stata software.
Results: A total of nine studies were included. The multivariate-adjusted results found that the total RR values of pancreatic carcinoma was 0.65 (95% CI: 0.53–0.80) for the highest vitamin B6 intake vs the lowest vitamin B6 intake, and there was no significant heterogeneity among studies (I2 = 42.0%, P = 0.087). Sensitivity analysis indicated that no single study leaded to an excessive change for the relation between vitamin B6 intake and pancreatic carcinoma risk.
Conclusions: This meta-analysis suggested that vitamin B6 intake could significantly decrease pancreatic carcinoma risk. However, further study is needed based on the limitations of the current analysis.
Disclosure Statement
There were no financial conflicts of interest in all authors; all authors participated sufficiently in the work to take public responsibility for appropriate portions of the content.
Authors Contribution
LL and YFP conceived and designed this study; YFP and MMH searched the databases, collected full-text reports and extracted the data; RH and BBD assisted to examine the data; YFP wrote and revised the manuscript. All authors approved the final version of the article.