Abstract
Background and Aims: Synbiotics found to be beneficial in breast cancer survivors (BCSs) through its antioxidant properties. The aim of this study was to assess the effects of synbiotic supplementation on edema volume and some oxidative markers among obese and overweight patients with BCRL.
Method: This randomized double-blind, placebo-controlled trial was conducted on 88 overweight and obese BCSs aged 18–65 years. All the subjects were given a specified low-calorie diet (LCD) and were randomly assigned into two groups to intake 109 CFU/day synbiotic supplement (n = 44) or placebo (n = 44) for 10 wk. Edema volume and serum total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GPx), and superoxide dismutase (SOD) concentration were measured at baseline and after the 10-wk intervention.
Results: Ten-wk supplementation with synbiotics leads to a significant reduction in serum MDA levels (P = 0.001) and an increase in serum SOD concentration (P = 0.007) compared to placebo. No significant changes were observed in serum GPx, TAC, and edema volume between groups.
Conclusion: Our findings reveal that 10-wk synbiotic supplementation along with a LCD program-reduced serum MDA levels and elevate the activity of SOD in overweight and obese patients with BCRL. However, its effect on serum GPx, TAC, and edema volume was not significant.
Acknowledgments
We would like to gratefully thank the participants for their support in the study. We are also thankful to Zist Takhmir Company.
Disclosure Statement
The authors have no conflict of interest to declare.
Additional information
Funding
MZ, MN, and SHH provided study concepts and designed the study. MN, SHH, HE, ZS, and MI helped in data acquisition. MZ checked quality control of data and algorithms. LJ, MZ, MN, SV, and AS took part in data analysis, interpretation, and statistical analysis. MN, MZ, AA, and MRL contributed to manuscript preparation, editing, and review.