Abstract
Background: Various biomarkers have been shown to assess and diagnose colorectal cancer in some researchers. Three indicators including PNI, SIR, GPS were used to predict the outcome for a variety of cancers in existing studies. However, few studies have analyzed the relationship between these biomarkers and different TNM staging. The aim of this study was to investigate the relationship between biomarkers and TNM staging and metastasis of CRC.
Patients and methods: Three hundred fifty-five eligible patients were included who were diagnosed with CRC from October 2012 to October 2018 in People’s Hospital of Yuxi City. Firstly, we separately calculated PNI, SIR markers and GPS in these patients. Next, the relationship between PNI and GPS with clinical factors were evaluated. Finally, the relationship between TNM staging and tumor metastasis was analyzed.
Results: Our results demonstrate that there were statistical differences between PNI and TNM staging, distance metastasis, NLR, PLR, LMR, GPS, CEA, CA199, ALB, L, N, M, PLT, Hb, CRP. GPS with age, TNM staging, distance metastasis, NLR, CA199, ALB, N, CRP have statistical differences. PNI is associated with SIR in patients with CRC, and in which PNI is negatively proportional to NLR and PLR, but positively proportional to LMR.
Conclusion: We attempt to combine PNI, SIR, GPS with TNM staging, and the results showed that the three indicators were closely related to TNM staging. Therefore, they can assist in the diagnosis of CRC and are closely related to TNM staging. Detection of three indicators is of important clinical value in the evaluation of TNM staging and metastasis prediction.
Acknowledgments
We appreciate the joint efforts of all participants. We are grateful to the cooperation of all participants and the joint efforts of all authors.
Availability of data and materials
The dataset supporting the conclusions of this article is included within the article.
Disclosure statement
The authors declare that they have no competing interests.
Consent for publication
The consents for publication of the individual person’s data have been obtained from the person themselves or their parents, in the case of children.
Additional information
Notes on contributors
Xuejing Bai
Xuejing Bai drafted the manuscript, analyzed and interpreted the data, revised the manuscript, approved the final version, and agreed to be accountable for all aspects of the work; Lei Feng planned the study, interpreted the data, revised the manuscript critically, approved the final version, and agreed to be accountable for all aspects of the work.