Tea Consumption and the Risk of Endometrial Cancer: An Updated Meta-Analysis

Abstract

Although the relationship between tea consumption and the risk of endometrial cancer has been previously analyzed in certain studies, the resulting information is still conflicting, and a previous meta-analysis yielded inconsistent results. Therefore, here, we aimed to perform an updated meta-analysis of studies on this subject in order to elucidate this relationship.

We searched the literature on the PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure databases for studies that were published prior to September 25, 2019, and all the relevant references were examined. Ultimately, we included eight studies, and seven of them were on black tea. We used the overall relative risk values (RR) and 95% confidence intervals (CI) to evaluate the risk. The synthetic RR of the eight eligible studies demonstrated that tea consumption was not relevant to the incidence rate of endometrial cancer (RR 1.06, 95% CI 0.96, 1.18). No publication bias was found. We detected significant heterogeneity among the studies (Q = 15.84, p = 0.027, I² = 55.8%). In conclusion, the results of this meta-analysis indicate that tea consumption is not relevant to the incidence of endometrial cancer. Further research and cohort studies should be conducted to validate our result.

Author Contributions

Liqi Zhang performed most of the analysis and drafted the manuscript. Junyan Ma did the data extraction. Kaiqing Lin revised the manuscript. Review of the initial and final drafts was done by Yifei Lv and Huihua Wang. Jun Lin designed and supervised the study. All the authors were informed of the content of manuscript and agreed to submit.

Disclosure Statement

The authors report no conflicts of interest.

Additional information

Funding

This work was supported by Grants from the National Natural Science Foundation of China under Grant No. 81771550.