Chemopreventive and Anti-tumor Potential of Natural Products in Oral Cancer

Abstract

Oral cancer (OC) is a multifactorial disease caused by isolated or combined risk factors related to tobacco, alcohol consumption, and human papillomavirus infection. It is an aggressive pathology with a low five-year survival rate after surgery, chemotherapy, and/or radiotherapy, frequently associated with severe side effects. Drugs with the highest anti-tumor effect are obtained from natural products with diverse biological and molecular activities and potential chemopreventive and anticancer properties. This review summarizes the natural products reported to have the chemopreventive and anti-tumor potential for OC treatment, showing that several of these compounds are promising candidates as chemopreventive agents, and those with the highest anti-tumor potential induce apoptosis and inhibit proliferation and metastasis-related processes. For this reason, natural products have the potential to be important preventive and therapeutic options for OC in the future.

Acknowledgments

The author thanks the Unidad de Investigación Básica Oral (UIBO) members for their accompaniment and support.

Disclosure Statement

No potential conflict of interest was reported by the authors.

Contribution Statement

Andrés Cardona-Mendoza:

• Conception the work

• Design the work

• Data acquisition

• Data Analysis

• Drafting the work

• Draft review

• Final approval

Geovanny Olivares-Niño

• Data acquisition

• Data Analysis

• Drafting the work

David Díaz-Báez

• Data acquisition

• Data Analysis

• Drafting the work

Gloria Inés Lafaurie

• Data Analysis

• Drafting the work

• Draft review

• Final approval

Sandra J Perdomo

• Conception the work

• Design the work

• Data acquisition

• Data Analysis

• Drafting the work

• Draft review

• Final approval