Prognostic Value of the Geriatric Nutritional Risk Index in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Abstract

This study aimed to quantitatively identify the prognostic and clinicopathological value of the geriatric nutritional risk index (GNRI) in non-small cell lung cancer (NSCLC) through a meta-analysis. The electronic databases PubMed, Web of Science, Embase, and Cochrane Library were thoroughly searched from inception to December 14, 2021. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the prognostic value of GNRI. Odds ratios (ORs) and 95%CIs were combined to estimate the clinicopathological significance of the GNRI in NSCLC. Seven studies with 2,023 patients were included in the meta-analysis. A low GNRI score was significantly associated with poor overall survival (OS) (HR = 2.01, 95%CI = 1.65–2.44, p < 0.001) and worse progression-free survival (PFS), recurrence–free survival (RFS), and cancer-specific survival (CSS) (HR = 1.81, 95%CI = 1.48–2.22, p < 0.001) in NSCLC. Furthermore, a low GNRI score was significantly associated with the histological type of non-adenocarcinoma (OR= 1.55, 95%CI = 1.19–2.03, p = 0.001) and Eastern Cooperative Oncology Group performance status (ECOG PS) ≥2 (OR= 2.81, 95%CI= 1.49–5.32, p = 0.001). A low GNRI score is a significant and effective prognostic marker for poor survival outcomes in patients with NSCLC. In addition, low GNRI score was correlated with higher ECOG PS scores.

Ethics Approval and Consent to Participate

No ethical approval or informed consent statement was required for this article.

Disclosure Statement

The authors declare that they have no competing interests.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request. All datasets generated for this study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.

Additional information

Funding

This study was funded by the Scientific Research Foundation of Hebei Province Health Commission (grant No. 20211577). The funder had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript.