Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study

Abstract

This study aims to assess early effects of chemotherapy on symptom alleviation, nutritional status, and mental health in elderly patients with advanced non-small-cell lung cancer (NSCLC). This prospective study included 45 NSCLC patients (32 males, 13 females) aged 65–82 years (mean age 70.0 ± 4.5 years) with good performance status. Assessments were conducted immediately after diagnosis and after two chemotherapy cycles, focusing on nutritional status (assessed with MNA questionnaire), quality of life (QoL, based on FACT-L and FACT-TOI questionnaires), lung cancer-related symptoms (based on LCSS), and mental health (based on PHQ-9 questionnaire). Despite significant alleviation of symptoms like cough, dyspnea, and body weight loss, there was no significant correlation between changes in symptoms burden and changes in nutritional status (r² = 0.122, P = 0.427), and change of patients’ mental condition (r² = –0.141, P = 0.255). No significant QoL changes were noted, but a decrease in severe depression frequency was observed. The improvement of patients’ mental condition was related strictly to the improvement of nutritional status (r² = -0.589, P < 0.001). The study highlights the vital link between nutritional status and mental health in elderly NSCLC patients, emphasizing the need for integrated care approaches that address both aspects to enhance treatment effectiveness and patient well-being.

Disclosure Statement

The authors have no conflicts of interest to declare.

Data Availability

The data that support the findings of this study are available from the corresponding author, WU, upon reasonable request.

Authors’ Contributions

Canception and design: Wioleta Umławska, Katarzyna Pawłowska-Seredyńska, and Irena Porębska; Collection and assembly of data: Wioleta Umławska and Irena Porębska; Data analysis and interpretation: Wioleta Umławska and Katarzyna Pawłowska-Seredyńska; Manuscript writing: All authors; Final approval of manuscript: All authors. All authors contributed to the article and approved the submitted version.

Additional information

Funding

The authors received no financial support for the research.