Reversibility of Tamoxifen® Retinopathy—A Ten-Year Follow-Up

Abstract

High doses of the non-steroidal oral antiestrogen tamoxifen (60 mg/m/day or more for at least 1 year) may cause decreased visual acuity due to retinal crystalline deposits and other ocular side-effects. A 56-year-old female patient suffering from pulmonary lymphangioleiomyomatosis (BML) with paraneoplastic estradiol production was presented with deterioration of visual acuity because of bilateral macular degeneration after an intake of 190–250 mg/day Tamoxpuren for five years. After discontinuing tamoxifen, ocular side-effects disappeared, perimetric and electrophysiological alterations almost normalized while visual acuity increased internal medical findings remained stable.

KEYWORDS:

• Breast cancer
• antiestrogen treatment
• electrophysiology
• retinopathy
• tamoxifen