Carboplatin-associated Cranial Neuropathy

ABSTRACT

Carboplatin is a platinum-based chemotherapeutic agent used for the treatment of many solid tumors. Peripheral neuropathy is a common side effect; but, to our knowledge, ocular motor cranial neuropathies have not been reported in the literature. We describe a case of persistent third and fourth nerve palsies after systemic administration of intra-arterial carboplatin for glioblastoma multiforme. Neither nerve regained function after carboplatin was stopped.

KEYWORDS:

• Carboplatin
• glioblastoma
• cranial neuropathy

Declaration of interest

The authors report no conflicts of interest.