Third Nerve Palsy as the Presenting Sign of Metastatic Endometrial Carcinoma with Lymphovascular Space Invasion

ABSTRACT

We present a case of endometrial carcinoma (EC) presenting with a third cranial nerve palsy due to metastasis to the cavernous sinus. Although the tumour was only stage 1B, histopathologic features including higher grade and lymphovascular space invasion (LVSI) increase the risk of recurrent and metastatic disease. To our knowledge, this is the first case of EC presenting as a third cranial nerve palsy in the English-language ophthalmic literature. Clinicians should be aware that the risk of metastatic EC including neuro-ophthalmic presentations depends upon not only stage and grade but also the presence of unique histopathological findings such as LVSI.

KEYWORDS:

• Third nerve palsy
• endometrial cancer
• metastasis
• lymphovascular space invasion (LVSI)

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Images have been de-identified, and this patient has provided written informed consent for the publication of these figures.

Declaration of interest

The authors have no conflicts of interest to disclose.

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