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ABSTRACT
Intracranial mass lesions may cause intracranial hypertension secondary to venous hypertension when they compress the dural venous sinuses (DVS) and may present with isolated papilloedema, mimicking idiopathic intracranial hypertension. We report a series of 16 patients with isolated papilloedema related to meningiomas compressing the DVS seen from 2012 to 2016 at three institutions. Correct diagnosis was delayed in 10/16 patients and treatment required a multidisciplinary approach, often with multiple sequential interventions, including combinations of acetazolamide, cerebrospinal fluid-shunt, optic nerve sheath fenestration, surgical resection of the meningioma, radiation therapy, and endovascular venous stenting. Two patients also received anticoagulation for venous thrombosis secondary to venous sinus compression.
Acknowledgements
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Declaration of Interest
The authors declare that there are no conflicts of interest. The authors alone are responsible for the writing and content of the article.
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Notes on contributors
Nancy J. Newman
Nancy J. Newman is a consultant for Gensight Biologics (France) and serves on the Data Safety Monitoring Board for Quark Pharmaceuticals (Israel) clinical trial, has provided expert testimony on the topic of optic disc oedema, and has received research support from NIH grants (R01-NS089694, P30-EY006360) and Research to Prevent Blindness Lew R. Wasserman Merit Award.
Valérie Biousse
Valérie Biousse is a consultant for Gensight Biologics (France), received research support from the NIH/PHS (P30-EY006360), NIH (R01-NS089694) and Research to Prevent Blindness.