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Neuro-Ophthalmology Volume 45, 2021 - Issue 4
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Review

Statins in Neuro-ophthalmology

Alvin TanDiscipline of Ophthalmology, Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, AustraliaORCID Iconhttps://orcid.org/0000-0003-0220-4018View further author information
ORCID Icon,
Clare FraserDiscipline of Ophthalmology, Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, AustraliaORCID Iconhttps://orcid.org/0000-0002-0379-7743View further author information
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Pauline KhooDiscipline of Ophthalmology, Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, AustraliaORCID Iconhttps://orcid.org/0000-0001-6266-306XView further author information
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Stephanie WatsonDiscipline of Ophthalmology, Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, AustraliaORCID Iconhttps://orcid.org/0000-0001-6699-1765View further author information
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Kenneth OoiDiscipline of Ophthalmology, Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8060-9374View further author information
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Pages 219-237 | Received 11 Nov 2019, Accepted 11 Apr 2020, Published online: 24 Jun 2020
 
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ABSTRACT

Statins are effective and well-tolerated hypolipidaemic agents which have been increasingly studied for their pleiotropic immunomodulatory and anti-inflammatory effects. Statins have potential therapeutic benefit in a range of neuro-ophthalmological conditions but may also induce or exacerbate certain neurological disorders. This literature review examines evidence from clinical and in vitro studies assessing the effects of statins in myasthenia gravis, myopathy, multiple sclerosis, neuromyelitis optica, idiopathic intracranial hypertension (pseudotumour cerebri), migraine, giant cell arteritis, Bell’s palsy, ocular ischaemia, stroke, Alzheimer’s disease and Parkinson’s disease.

Declaration of interest statement

KGO and SLW have a patent on topical Atorvastatin as a novel tear film stabiliser.

Additional information

Funding

SLW is supported by a Sydney Medical School Foundation fellowship.

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