CASE REPORT Rosai-Dorfman Disease Recurrence with Bilateral Orbital Masses Following Immunosuppressant Therapy

Abstract

Rosai-Dorfman disease is a rare condition characterised by massive lymphadenopathy involving the orbit in 11% of cases. Immunohistochemical analysis remains key to the diagnosis with characteristic immunohistochemical S100 staining of histiocytes and lymphocyte phagocytosis. We report the case of a 43-year-old female with recurrence of bilateral orbital Rosai-Dorfman disease following long-term immunosuppressant therapy. Long-term follow-up is advised in conservatively managed patients and surgery may offer more definitive treatment.

Keywords:

• Rosai-Dorfman disease
• sinus histiocytosis
• orbital involvement
• lacrimal gland