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Experimental Lung Research Volume 31, 2005 - Issue 4
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AEROSOLIZED HYALURONAN LIMITS AIRSPACE ENLARGEMENT IN A MOUSE MODEL OF CIGARETTE SMOKE–INDUCED PULMONARY EMPHYSEMA

Jerome O. Cantor St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
,
Joseph M. Cerreta St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
,
Marcos Ochoa St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
,
Shuren Ma St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
,
Tony Chow St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
,
Gabriele Grunig St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
&
Gerard M. Turino St. John's University School of Pharmacy and Allied Health Sciences, Jamaica, New York, USA; and St. Luke's-Roosevelt Hospital Center, New York, New YorkUSA
 show all
Pages 417-430 | Received 16 Jun 2004, Accepted 21 Sep 2004, Published online: 02 Jul 2009
 
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Abstract

This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke–induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 μm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.

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