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ARTICLES

Ribosome–Lamella Complex Precursors in Acute Monocytic Leukemia: A Study of 6 Cases

, MD, , , BSc, , BSc, , MD, , BSc & , MD show all
Pages 135-140 | Received 28 Sep 2006, Accepted 02 Jan 2007, Published online: 10 Jul 2009
 

Abstract

The ribosome–lamella complex (RLC) is a cylindrical structure composed of annular lamella associated particles, regarded as ribosomes, around a central core, which is best known in hairy cell leukemia. RLC has been presumed to originate from aggregating rER and ribosomes. Incomplete and maturing RLC structures have been called RLC precursors (pre-RLC). The present paper investigates the various architectural aspects of pre-RLC and the ultrastructural characteristics of the blasts in 6 cases of acute monocytic leukemia (M5) in which these structures occur. Blasts bearing pre-RLC contained irregular nuclei with less heterochromatin and a prominent nucleolus, and many cytoplasmic organelles in an abundant cytoplasm. The findings indicate that pre-RLC might result from an asymmetrical differentiation of organelles in blasts associated with expression of CD117 and CD56 but default of CD14 in M5.

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