The ultrastructural effects of surgical treatment of hydrosalpinx on the human endometrium: a light and electron microscopic study

ABSTRACT

Hydrosalpinx is a disease commonly observed in women and characterized by the obstruction which is in the shape of a fluid-filled sac at the distal part of tuba uterina closed to the ovary. In this study, we aimed to obtain endometrial tissue samples from the hydrosalpinx patients, before and after the surgical treatment and compare these endometrial tissue samples by using light and electron microscope. Endometrial tissue samples were obtained from the 24 women with bilateral hydrosalpinx range 19–46 years before and after the surgical treatment, and normal endometrial tissues were collected from five women without hydrosalpinx and evaluated as a control group. In endometrial samples of hydrosalpinx patients; it was observed that large and unregulated interstitial spaces representing the organellar destruction, membranous whorl structures associated with organelle destruction, thinning in the surface epithelium, decreasing in numbers of microvillus and pinopodes in microvilli cells, increasing in heterochromatin and picnotic changes in the nucleus, expansion, and vacuolization in the endoplasmic reticulum cisternae in the apical cytoplasm and intraepithelial macrophages and lymphocytes were rised in number. Although mild structural changes were observed in endometrial tissues obtained after surgical treatment of hydrosalpinx, surface epithelium, glandular and stromal cell structures were more similar to control endometrial specimens. In conclusion; serious structural changes have occurred in endometrial tissues of hydrosalpinx patients. These structural abnormalities have removed after surgical treatment so it is considered that surgical treatment is effective in patients with hydrosalpinx.

KEYWORDS:

• Endometrium
• human
• hydrosalpinx
• surgical treatment
• ultrastructure

Acknowledgments

This study was supported by a grant from Cukurova University Scientific Research Projects Coordination Unit (Project number: TYL-2015-4528). This work was partially presented at the 23rd National Electron Microscopy (EMK2017) Congress in Antalya-Turkey.

Disclosure

No potential conflict of interest was reported by the authors.

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Declaration of Interest Text

No potential conflict of interest was reported by the authors.