Histological and biochemical studies on effect of Sofosbuvir (Sovaldi) on adult male albino rat kidney

ABSTRACT

Sofosbuvir (sovaldi) is the backbone of many anti‐HCV drugs. We aimed to demonstrate the effect of sofosbuvir on the adult male albino rat kidney. Sixty adult male albino rats were used. The animals were divided equally into 2 main groups (I and II), and each group was divided equally into 3 subgroups (A, B, and C). In group I (control group), each rat was gavaged 0.5 ml distilled water daily for 4 weeks. In group II (sofosbuvir treated group), each albino rat was gavaged 0.5 ml distilled water containing 7.2 mg sofosbuvir daily for 4 weeks. The rats were sacrificed at the end of the 4th week (subgroups IA and IIA), 6th week (subgroups IB and IIB), and 8th week (subgroups IC and IIC) from the start of the treatment. The kidneys were used for histological study while blood samples were used for biochemical study. The obtained data were statistically analyzed. Sofosbuvir (sovaldi) induced pathological changes that gave the criteria of acute Kidney injury in the adult male albino rats. The pathological changes were confirmed by elevation of serum level of urea and creatinine. After 2 and 4 weeks of drug withdrawal, the kidney incompletely recovered. We concluded that sofosbuvir induced criteria of acute tubular injury in the kidney of the adult male albino rats. This renal injury was proved by histological and biochemical studies. These insults were incompletely reversible after the end the treatment.

KEYWORDS:

• Sofosbuvir
• kidney
• adult
• male
• albino
• rat

Acknowledgments

The authors wish to express their appreciation to the Regional Mycology and Biotechnology Center, Al-Azhar University, Cairo, Egypt.

Disclosure Statement

No potential conflict of interest is relevant to this article.

Statement of Ethics

The protocol was performed following the guidelines of the Laboratory Animal Care and Use Regulations and proved by the ethics review broad of the Faculty of Medicine for Girls, Al-Azhar University, Egypt. Approval No. FMG-IRB Decision/20210523.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was personally funded.