The crystallization patterns of carbamazepine precipitated from a confined microemulsion reservoir were studied by DSC, TGA, Powder XRD, single crystal XRD, SEM, and optical microscopy. The results suggest that interfacial fast nucleation and slow growth from O/W microemulsion leads to a selective, large, and better‐ordered single crystals of dihydrate form with primitive monoclinic unit cell with parameters a=10.16 Å, b=28.70 Å, c=4.93 Å, β=103.33°, cell volume of 1400.7 Å3, and space group P21/c. The crystal structure, as well as the habit, are strongly influenced by the heat dissipation and prefered molecular orientation at the interface.
The results presented in this paper part of Anna Kogan's Ph.D. dissertation in Applied Chemistry, The Hebrew University of Jerusalem, Israel.