Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Anethole Trithione by Combined Use of Surfactants

Abstract

The characteristics of self-nanoemulsifying drug delivery system (SNEDDS) of Anethole trithione (ATT) for oral administration by the combined use of surfactants were investigated. In combination with surfactants, the SNEDDS provided smaller particle size, more oil loading, and shorter emulsification time. ATT from the SNEDDS rapidly dissolved in dissolution media whereas the ATT tablets showed different dissolution patterns according to the dissolution media. Furthermore, loading of ATT in SNEDDS improved the stability of ATT, and particle size of ATT nanoemulsion generated upon dilution was kept constant both in simulated gastric fluid and simulated intestinal fluid without enzyme.

Keywords:

• Anethole trithione
• dissolution
• self-nanoemulsifying drug delivery system
• surfactant

Acknowledgments

The authors would like to thank the supports of research fund for the excellent young teachers by SMEC and ECUST.