Abstract
The release profiles of bovine serum albumin nanoencapsulated into an enteric copolymer (methacrylic acid/ethyl acrylate blended with poly (ethylene glycol)) show an effective protection for this protein from the stringent pH gastric environment. The nanoParticles (nP) yield of about 90% and encapsulation efficiency of 77–78% indicate a successful control of the process. The experimental evidence leads to physical entanglements between PEG and the copolymer be considered as the driving factor to modulate the release.
Acknowledgements
The authors are grateful to the Red de Macrouniversidades for the financial support. We also thank Dr. Genoveva Hernández-Padrón, Mr. Miguel A. Canseco, Dr. Sergio Jiménez, and Mr. Francisco Rodríguez for their kind assistance in various stages of this project. The copolymer used was a contribution from BASF (Germany).