Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000

Abstract

The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407). Consequently, the objective of this study was to evaluate P407 as a carrier for nimodipine solid dispersions and to compare its solubility and dissolution rates with those from polyethylene glycol (PEG 6000). The solid dispersions were prepared by the hot melting and solvent methods and they were characterized by FTIR, DSC, solubility, and dissolution tests. The results indicated a three-fold increase in solid dispersions solubility in the presence with P407 than those prepared with PEG.

Keywords:

• Drug dissolution
• PEG 6000
• poloxamer 407
• solid dispersions
• solubility

Acknowledgments

The authors would like to thank to Humberto Gomes Ferraz for the DCS equipment used in analytical procedures, as well as to Leticia Carpentieri Rodrigues for her very useful contribution in rx analysis.